Investigation of mechanosensitive molecular pathways underlying activation of cell signaling cascades involved in the regulation of cell migration
Expected outcome: Understanding of molecular mechanisms underlying the cell-guiding function of filopodia and crosstalk between mechanosensitive processes and small Rho GTPases, which play the central role in many physiological processes, including embryonic development, wound healing, neurite growth cone pathfinding, cancer development, etc.
Learn moreStudy of molecular mechanisms involved in the regulation of the nucleus size and a potential effect of the latter on chromatin organization in living cells
Expected outcome: Understanding the molecular mechanisms responsible for the mechanotransduction of extracellular forces into epigenetic chromatin changes that lead to matrix-dependent differentiation or dedifferentiation of living cells.