Development of a general theoretical framework and the fastest (in the world) computational algorithm capable of predicting the conformation of DNA and changes in its interaction with DNA-binding proteins under mechanical and geometric constraints at the single-molecule and mesoscale levels.
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Development of a numerical algorithm for predicting the mesoscale organization of the cell genome based on the physicochemical properties and architecture of individual nucleoprotein complexes. Discovery of the piezoelectric behavior of the cell nucleus and its potential role in nuclear organization.
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Discovery of the role of formins and myosin IIA motor proteins in the regulation of the mechanosensory function of filopodia.
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Discovery of force-induced Ca2+ signaling mediated by L-type Ca2+ channels in filopodia, which results in activation of Ca2+-sensitive calpain protease involved in the regulation of cell adhesion complexes.
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